Clinical trials need to devise ways to explore patients' experiences more directly than through clinicians' diagnoses and symptom rating scales.
About a third of all oncology prescriptions are off-label (Conti et al., 2013), and theories of tumor physiology help clinicians to extend findings from trials in order to devise treatments for patients who might not have met the initial criteria for treatment with the drug.
Malkus, the only defendant to testify, was convicted of six mail fraud counts, acquitted on 12. Evidence showed that the judges handled dozens of Frega's cases, received hundreds of telephone calls from him at their homes and offices, and met secretly with him to devise trial strategies without notifying opposing counsel.
There is no need to force routes through certain waypoints, to determine landscape conductance a priori or through piecemeal trial-and-error or to devise complex methods to select the earliest data points, as was done in studies with similar aims [16] [20], [31], [65].
It never made it out of the Senate Armed Services Committee, leaving the administration to devise the trial system itself.
CryoCor and other companies planning or currently conducting trials said that it could take as long as six years to devise and complete such trials.
Technical challenges posed by the thoracic aorta have resulted in a significant time-lag (since release of abdominal aortic aneurysm endografts), testing the ability of engineers and physicians to devise and complete trials successful enough for FDA approval of thoracic endografts.
Because of the nature of esthetic procedures, where patients are not referred, but elect to have treatment by the practitioner of their own choosing, it is challenging to devise meaningful clinical trials.
To devise and test techniques to blind outcome assessors in trials of hip fracture fixation.
Dr. Giannini, who received consulting fees from the companies for helping to devise their pediatric clinical trials, said that no cases of cancer were seen in the clinical trials that led to Enbrel's approval for pediatric use.
