Exact(26)
The positive control group is essential to define the sensitivity of the trial to detect a drug's effect on cardiac repolarization.
A successful mixed modes trial requires a "faithful migration," measurement equivalence established between modes, and carefully planned implementation to minimize the risk of increased measurement error impacting the power of the trial to detect a treatment effect.
Due to resource and time constraints of a phase 2 trial, we did not power the trial to detect a significant effect on DV.
The sample size of 23 dogs was based on the power of the trial to detect a specified clinical benefit on the PVF.
A trial to detect a 4% reduction in mortality with 80% power would require a total sample size of around 3500 (i.e. approximately 1745 patients in each arm).
The power of this trial to detect a difference in primary outcomes was further improved by the combination of the two decision aid arms.
Similar(34)
We have powered this trial to detect an effect size of 0.4.
The power of this trial to detect an absolute difference in 5-year survival of 2.9% as observed in the QUASAR 1 trial is 16.6%.
Some would argue that it may have been unrealistic to design a randomized controlled trial to detect an ARR of10% in septic shock.
It has been estimated that a trial would require a minimum of 30,000 patients, much larger than any clinical trial, to detect an association with iDILI based on a frequency of 1/10,000 (Holt and Ju 2006).
To illustrate this lack of sensitivity, we estimated that to power the Davenport trial to detect an AR of 20 cases per 10,000 persons per year, a risk similar to that estimated by the risk assessment, would require a sample size of 8 million individuals; to detect an AR of 100 cases per 10,000 persons would require 416,000 individuals.
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