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This protocol was the first interventional trial to be designed to demonstrate that CTC-driven management of chemotherapy improves the outcome of metastatic breast cancer patients.
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Part of our aim is to provide clarification allowing for larger randomised trials to be designed in the future.
A randomized clinical trial needs to be designed to compare the intervention with a control condition.
Further randomized clinical trials are required to be designed in order to determine the exact outcomes of combined treatment.
To be timely, trials should be designed to be as small as realistically possible to obtain clinically relevant results.
However, a large randomised control trial should be designed to confirm the efficacy of this treatment.
Trials must be designed to produce reliable results.
Clinical trials should be designed to answer those questions.
Clinical trials should be designed to answer unsolved questions.
It is imperative that therapeutic trials be designed to reflect the true population of people with COPD.
Among the included 12 trials, 8 trials were designed to compare G-CSF with placebo and 4 trials compared GM-CSF with placebo.
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