With the inability to compose such studies in human clinical trials, this method is non-invasive and non-destructive.
Although autologous tissue-engineered tabularized urethras have been successful in clinical trials, this method could be an alternative treatment for urethral reconstruction.
A further trial comparing this method of MIST with standard intubation in very preterm infants (23 26 weeks gestation) has now been completed, and the results are awaited.
In the initial clinical trial investigating this method, Barkholt et al. expanded CD56+ cells (NK and NK-T cells) from PBMCs of haploidentical donors as described above [ 51].
Over the course of the trial, this allocation method aims to optimise patient outcomes and more patients will receive the superior treatment.
The CATCH protocol, stated that for emergency admissions, blood samples could be taken prior to seeking consent: "Because blood sampling from all catheter lumens is the standard of good practice used in the trial, this sampling method should be used for patients who have not yet been approached for deferred consent".
Dr. Lavie and coauthors wrote, "Although B.M.I. is the most common method to define overweightness and obesity in both epidemiological studies and major clinical trials, clearly this method does not necessarily reflect true body fatness, and B.M.I./body fatness may differ considerably among people of different age, race and sex".
Single trials lack this method of estimating the impact of such factors, and this affects the credibility of the results.
This paper reviews recent published trials using this method and describes the reasons authors gave for using the method, examines the crossover rates, and looks at the quality of identified trials.
None of the trials using this method, however, met the inclusion criteria for our analysis.
