In the absence of any directly comparative trials, this article seeks to place the various considerations of their efficacy in perspective.
Re "Surgery for Epilepsy Gains Urgency in Trial" (March 13): This article demonstrates the need for better treatment for patients with epilepsy, but no mention was made about the very few patients who actually qualify for surgery.
Using data from a large well-characterized clinical trial population, this article aims to illustrate the impact of cohort enrichment and study duration on sample size requirements for IPF clinical trials in which death alone or death plus hospitalization serve as the primary end point.
One article reported a systematic comparison of evidence from observational studies versus randomized trials [ 40]; however, there was no clear statement that the non-randomized studies included were primary prevention studies, and pooled data on the randomized trials in this article are already included in the meta-analysis by Rothwell et al. [ 34], which is included in Table 5.
Major parts of the CopenHeartSF methods section and trial design in this article are similar to other randomised clinical trials, Copen HeartIE 50 CopenHeartRFA 51 and CopenHeartVR.
In the trial described in this article, we introduce patient empowerment into a whole new field of care: insurance medicine.
The trial described in this article has been conducted since 2003 in the Nouna Health District, a region located in north-western Burkina Faso about 300 km from the capital Ouagadougou [ 19].
For each trial presented in this article, all parameters, except kin_HbA1c and kout_HbA1c, were estimated using a nonlinear mixed-effects approach as done for the development of the model (Table 2 ).
The proposed trial presented in this article will investigate the effects of a fall prevention exercise program developed by an expert panel on intrinsic fall risk factors (i.e., balance, strength / power), body composition, cognitive function, psychosocial well-being, and falls-self efficacy.
