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For the vaccine trials that gave the greatest departures from normality (a hepatitis A vaccine [23] and a S. pneumoniae type 19F vaccine [24] trial), the distribution of the log transformed data from other 3 other trials examined with each of these vaccines were not significantly different to a normal distribution (data not shown).
In this trial, the distribution of different stages of encephalopathy was presented in four different groups of children.
However, for the group of trials after the learning trial, the distribution was much closer to a uniform distribution (χ = 20.53, p=0.015, Figure 3I).
However, from Fig. 3 we see that, in the context of a three-stage drop-the-losers trial, the distribution of is highly skewed.
Since randomization only holds within a trial, the distribution of covariates may vary across studies for a particular type of comparison, as well as between different types of comparisons.
Looking at the seven unknown families collected at the farm, at three stages of the experiment; infection, sampling and after termination of the EB trial, the distribution of family representation in the overall population changed clearly between the start of the experiment and after termination of the EB trial.
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Figure 4c presents for all trials and across subjects (21,600 trials) the distribution of presented target directions of motion.
For the principal cells that exhibited significant spike-phase coherence to a given rhythm during All Trials, the distribution of their coherence to all possible combinations of rhythms is shown separately for correct and incorrect trials.
For the interneurons that exhibited significant spike-phase coherence to a given rhythm during All Trials, the distribution of their coherence to all possible combinations of rhythms is shown separately for correct and incorrect trials.
As expected, based on prior randomized trials, the distribution of posterior mean ORRs for trials testing monoclonal antibodies was shifted toward higher ORRs relative to the distribution for trials not including monoclonal antibodies (54% vs 46%, p-value of 0.0042 based on a Kolmogorov-Smirnov test).
The primary outcome measure for ASb, ASc, and ASl trials was the distribution of trials around SAS.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com