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The aim of this study was to evaluate systematically, based on eight methodological standards derived from a hypothetical randomised controlled trial, the design of studies investigating the intergenerational transmission of child physical abuse.
This overview summarizes the results of that trial, the design of other large-scale trials, and advances in understanding of the molecular mechanisms underlying the effect of other promising agents, including dutasteride, selenium, Vitamin E, Vitamin D, COX-2 inhibitors, lycopene, and green tea.
The intervention is being evaluated in a single-blinded, randomised controlled trial, the design of which is described in detail elsewhere (Kinner et al. 2013).
The intervention will be tested within a feasibility trial, the design of which will depend on the intervention.
The rationale for the trial, the design, and the strengths and limitations of the study are discussed.
We performed a cohort analysis of the ProActive trial, the design of which is described in detail elsewhere [ 21].
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HJL has collected the data of the trial, designed the study and drafted the manuscript.
They also said the trial design changed as the trial progressed.
29 Another critical element of the trial design is the selection of the patient population.
D.R.W.J. led the trial design, oversaw trial conduct and provided a significant contribution to manuscript writing.
EM participated in the trial design, developed the statistical plan and drafted the manuscript.
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