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The intended participants in this trial suffer from complex problems which can adversely influence clinical care.
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All the patients in this trial suffered from tension headaches.
The trial suffered from a number of issues.
Nonetheless, this trial suffers from limitations due to the lack of comparability between groups and differential attrition bias.
28 However, only 10% of the patients in the RECODE trial suffered from a depression at baseline.
Clearly, this trial suffered from a more heterogeneous patient population than intended, with many patients harboring glioblastoma-like tumors and only a minority of the patients having the chemotherapy sensitivity-associated 1p/19q co-deletion.
This trial suffers from a number of design flaws, not least of which is the fact that delivering two cycles of carboplatin at AUC 9 in addition to six cycles of cisplatin paclitaxel adds a longer duration of chemotherapy and an increased cumulative dose of platinum, thus unbalancing the trial in favour of the research arm, irrespective of the mode of administration.
Analyses comparing randomized to nonrandomized clinical trials suffer from the fact that the study populations are usually different.
In fact, clinical trials suffer from many ethical and economical limitations [ 5].
Comparisons of toxicity between trials suffer from differing patient groups and definitions of haematological toxicity.
Individually randomised trials are generally preferred because cluster trials suffer from a loss of power due to clustering effects.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com