The current study presents the findings from a randomized control trial study involving the assignment of 168 second grade students to a RR, wide reading (WR), or business as usual condition.
However, in longitudinal and cluster trial studies involving repeated measure of parameter estimates this bias can lead to invalid inferences regarding measures of effect such as risk ratios (RR) or OR [ 17].
The review's inferences are also limited by the inconsistent outcome measure used across trials: studies involving endometrial destruction and Mirena focused on comparing reduction in bleeding, while hysterectomy trials focused on women's satisfaction, quality of life, and use of resources.
A major chemoprevention trial – the Beta-Carotene and Retinol Efficacy Trial (CARET) Study – involving a total of 18,314 smokers, former smokers, and workers exposed to asbestos, however, resulted in 388 new cases of lung cancer during the average follow-up period of 4 years.
Of the 23 trials, one study involving perioperative neurosurgical patients was excluded because some of the data had already previously been published in two papers that were included in the meta-analysis.
28 The second 24-week trial, "Study L", involved 249 T2DM patients inadequately controlled on sulfonylurea therapy.
While not a randomized trial, another clinical study involving 14 patients was able to quantify the advantage of using autologous bone with platelet gels compared to autograft alone.
The CRASH trial did not involve any extra travel by participants, whereas most of the trials in our study involved several visits.
Because all trials in this study involved the presence of an object (i.e., there was always something to "see"), the question remains as to what happens when hallucinating participants are primed in the absence of a veridical percept.
40 Most of the trials in our study involved a reduced dose or duration of administration of rasburicase (Table 5).
