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For example, DL error rates for meta-analyses of five studies ranged between 5.7% for equally sized trials and 14.7% for mixtures of trial sizes (Table 1).
Illustrative examples of calculations of trial sizes for each endpoint type are included.
For equal trial sizes, the error rates of the HKSJ method were very appropriate.
The left side of Figure 1 shows the error rates for the DL method for the simulated mixtures of trial sizes.
The corresponding probabilities of being cost-effective are estimated by performing 42 (7 compliance losses * 6 trial sizes) multivariate sensitivity analyses.
Second, we looked into series of trials with different trial sizes, i.e. the percentage of large trials was 25%, 50% or 75%, e.g. a series of one large trial and three small trials.
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Fischetti read the transcript of the trial, sized up his potential client, and took the case pro bono.
In addition, the trial size was small with clear limitations in statistical power.
For randomized trials, (4) trial size and (5) unequal randomization were also assessed.
We empirically evaluated whether there is also a relationship between trial size and heterogeneity.
Trial size varied from 28 to 1813 participants; however, most were small, with a median of 134 participants.
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