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Everyone who takes a plea or goes to trial should consider taking an appeal.
A clinician setting up a phase II trial should consider the likely mechanism of action the drug will have and choose an end-point that provides high power for that scenario.
This indicated a potential flaw with the search strategy, and a future large-scale trial should consider including a cancer question as part of the screening questionnaire given to patients, if the intention remains to exclude patients with cancer.
A clinician who is interested in running a phase II trial should consider how the treatment is likely to bring about improved long-term survival (if that is the phase III end-point to be considered).
The second limitation is our inclusion of patients having a positive belief regarding either acupuncture or NSAIDs treatment, and therefore a future large-scale trial should consider including a question as part of the screening questionnaire about patients' expectations regarding each treatment.
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Future trials should consider examining adjuvant treatment escalation in patients with >5 lymph nodes.
Future trials should consider standardizing the amount of available glycemic carbohydrate in study meals that assess the effect of 'catalytic' doses of fructose from whole foods.
Future trials should consider acute and extended use of novel agents to better match the pathophysiology of decompensation and recovery from acute HF.
Future randomized controlled trials should consider the dose of ethanol and the duration of ethanol consumption and abstention in the experimental design.
Future trials should consider screening for depression before recruiting patients.
The design of future vaccine trials should consider diverse regional epidemiological scenarios.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com