Many readers have asked if Harold Burson's Nuremberg trial scripts, which were the subject of my last column, are available online.
The use of intravenous (IV) ocrelizumab for the treatment of RA was studied in four phase III, international, randomized, double-blind, placebo-controlled trials: SCRIPT, STAGE, FILM, and FEATURE.
An analysis of all the phase III trials SCRIPT, STAGE, FILM, and FEATURE concluded that ocrelizumab at doses of 500 mg plus MTX treatment groups were associated with a higher rate of serious infections compared to placebo plus MTX, whereas ocrelizumab 200 mg doses plus MTX did not show higher serious infection rates [9].
Tonally, Denial starts on wobbly ground with the introduction of American academic Deborah E Lipstadt (Weisz), the woman on whose book, Denial: Holocaust History on Trial, David Hare's script is based.
Later, Mr. Anwar added: "The court's integrity has been completely compromised and bears all the classic symptoms of a show trial where the script has been effectively written and the outcome a foregone conclusion".
One of the most successful interventions for pregnant smokers was the Smoking Cessation or Reduction in Pregnancy Program Treatment (SCRIPT) trial.
Based on Social Cognitive Theory [ 25], the SCRIPT trial increased quit rates from 2%to20%0% and significant reduction rates from 7%to30%0% [ 26- 29].
Similar trends were observed in the SCRIPT trial, where a higher rate of serious infections appeared to be driven largely by patients from Japan. 10 Both doses of OCR rapidly depleted B cells shortly after infusion.
Joe Nocera's comments on the Nuremberg trial ("The Nuremberg Scripts," column, Oct. 1) need to be placed within the appropriate historical context.
These data are similar to those observed for rituximab in MTX-naive patients with RA 7 and in two related OCR phase III trials, STAGE and SCRIPT.
