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We conclude that Alzheimer's disease prevention trials can enroll elderly participants with minimal effect on trial retention and that enriching for older individuals with memory complaints might afford efficient trial designs.
In equivalence (or non-inferiority) trials, the active control is usually an established antiepileptic drug (AED) such as carbamazepine or valproate, and outcome parameters may include proportion of patients achieving a predefined (for example, 6-month) seizure remission or the proportion of patients remaining in the trial (retention rate, a combined measure of efficacy and tolerability).
After a two week period of EE, mice received a single probe trial (retention), followed by five days of training (4 trials per day) to the same platform position as in the baseline test and a single probe trial (re-acquisition).
Overall women in the other trial arms were relieved that evaluation of 0.5% gel was continuing, no-one withdraw from the 0.5% and placebo groups as a result of the discontinuation, and trial retention and gel adherence was not affected in anyway.
One TM had used case management to improve trial retention.
A variety of factors can impact trial retention.
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For four trials, retention was the number of participants remaining in the trial.
For 34 of the included trials, retention was response to postal and electronic questionnaires with or without medical test kits.
During repeated motor-learning trials, retention time improved significantly in older Ifnb +/+ mice compared to Ifnb –/– mice from age 3 months, showing that reduced motor-learning in Ifnb –/– mice was associated with aging.
Most interviewees thought newsletters were useful for keeping participants and site clinicians informed about trial recruitment, retention and general trial news.
The other host trials included multiple retention trials (one unpublished for the retention trials by Bailey 1 and Bailey 2).
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