GlaxoSmithKline lost 13p to 1637.5p after a disappointing trial result for an experimental heart drug.
But another big faller is AstraZeneca after a disappointing trial result for its cholesterol drug Crestor, its biggest selling product.
But Mr. Humer of Roche said he did not see the trial result as a "binary event" that would be decisive for Avastin's future.
As leading shares ended the quarter on an upbeat note, Shire was an exception after the drugs group reported a disappointing trial result.
In a buy note Investec said: "Following today's trial result we expect GW to file for approval with the MHRA (the European regulator) within the next three months.
After bribery allegations in China, a disappointing trial result for cancer treatment Mage-A3 and reports that generic competition to its best selling lung drug Advair was a step closer, there was a positive outcome in the US.
The district attorney's office wants the settlement talks, being held under the auspices of the Westchester County Surrogate's Court, held at bay to prevent prosecutors from losing a strategic edge, should indictments and a criminal trial result, according to the people who have been briefed.
Dr. Christopher B. Granger, the study's lead author and a professor of medicine at Duke University, said: "I think this is a profound trial result that will have a major impact on the practice and management of patients with atrial fibrillation.
Given a valid clinical trial result, it is equally important to determine whether the findings can be generalized.
The clinical trial result is highly consistent with our observation on mouse model, and making it a solid basis for future large-scale clinical study.
Figure 3 shows the trial result from the model where the optimal location (triangle mark) is 183 km distant from the reported epicenter (square mark).
