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There were 28 patients who received radiation doses of 60 Gy (66 Gy: 13 patients, 72 Gy: 13 patients, 78 Gy: 2 patients) and all these patients were included in a phase I dose-escalation trial reported previously.
The data were obtained prior to the implementation of an intervention trial reported previously [ 48], and approved by the Hunter New England Local Health District (No. 09/06/17/4.03) and the University of Newcastle Human Research Ethics Committees (No. H-2010-1116).
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Results of this clinical trial were reported previously (Buzdar et al, 2005).
The rationale and design of the ORIGIN trial were reported previously (9).
Treatment-emergent adverse events during the initial 30 weeks of the trial were reported previously (17).
Our analyses provide no evidence of such an increase in mortality either in the glucose-lowering arm of the ADVANCE trial as reported previously (8) or in the present analyses.
This response was quickly habituated within a few trials as reported previously [ 3].
Trial design and the identification of several prognostic markers based on the trial data were reported previously [ 23– 28].
The main outcomes of this trial have been reported previously.
Details of the methodology used in the ACHOIS trial have been reported previously [ 2].
Details of adverse events occurring during the ATHENA trial have been reported previously.
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