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These predictions have helped set expectations for phase II results in advance of trial readout, inform early planning for subsequent development, increase understanding of the impact of statin background therapy, and support biomarker interpretation.
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Since the C-terminal truncated Aβ1 14/15 species are elevated after inhibition of γ-secretase, their use as a readout for trials aiming at the modulation of γ-secretase has been suggested [ 88].
It was recommended that neutralizing antibody assays be more extensively employed, for example in relation to the antigenic characterization of influenza viruses to complement the routinely used HI tests for the identification of viruses to include in vaccines and as a readout for clinical trials of influenza vaccines.
Pelletier advised the recording of total joint replacements after 6 years of follow-up; these data, which would serve as an adequate readout for DMOAD trials, can be easily collected by means of questionnaires.
The physiological and biochemical readout from the aforementioned clinical trials will be key in our understanding and the current study will inform such analyses.
Finally, in this experiment, we also had a direct behavioural readout of decision formation on every trial as subjects could respond at any time after decision onset.
Run lshw to see a readout of your installed hardware.
To detect such events requires a moment-by-moment (Briggman et al., 2005; Yu et al., 2009) readout of brain states on single trials (Churchland et al., 2007; Afshar et al., 2011).
A phase I clinical trial of PF-03084014 is ongoing and the data readout should inform on patient selection and future development of the compound for CRC.
For example, how does one plan and interpret a trial to validate van't Veer et al.'s observations where the readout is not just one marker but between 70 and 100 markers?
Pilot studies suggest that optical imaging methods (for example, diffuse optical spectroscopy) can provide an early readout of treatment efficacy [ 15], and larger, multicenter trials of optical imaging are under way.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com