Mao, S. et al. Sodium tanshinone IIA sulfonate for reduction of periprocedural myocardial injury during percutaneous coronary intervention (STAMP trial): rationale and design.
Potential reasons for the negative results can be classified into three categories: first, issues regarding trial rationale and preclinical study results; second, pharmacological issues; and third, clinical trial design and methodology issues.
The steps to health employee weight management randomized control trial: rationale, design and baseline characteristics.
Mentz, RJ, Tulsky, JA, Granger, BB, Anstrom, KJ, Adams, PA, Dodson, GC, Fiuzat, M, Johnson, KS, Patel, CB, Steinhauser, KE, Taylor, DH, O'Connor, CM, and Rogers, JG. "The palliative care in heart failure trial: Rationale and design". American Heart Journal 168, no. 5 (January 1 , 2014: 645-651.e1.
Mentz, RJ, Tulsky, JA, Granger, BB, Anstrom, KJ, Adams, PA, Dodson, GC, Fiuzat, M, Johnson, KS, Patel, CB, Steinhauser, KE, Taylor, DH, O'Connor, CM, and Rogers, JG. "The palliative care in heart failure trial: rationale and design". American Heart Journal 168, no. 5 (November 2014): 645-651.e1.
The trial rationale was unclear in 4 (4%) trials.
The Living Donor Lost Wages Trial: Study Rationale and Protocol.
Valsartan in acute myocardial infarction trial (VALIANT): rationale and design.
The effectiveness of MAINTAIN is being evaluated in an ongoing trial, the rationale and procedures of which are reported herein.
The paper describes the theoretical foundation for EARLY ALLIANCE, the goals of the prevention trial, the rationale for design choices, and the methods employed.
"The PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) trial: study rationale, design, and baseline patient characteristics". American Heart Journal 150, no. 4 (October 2005): 643-649.
