Exact(3)
A randomized trial, Radiation Therapy Oncology Group trial 9902, was undertaken to determine whether adjuvant chemotherapy with paclitaxel, estramustine, and etoposide (TEE) plus AS+RT would improve disease outcomes with acceptable toxicity.
During the course of the trial, radiation doses were collected and reviewed; the findings of this work have been published elsewhere (Young, 2002).
One such completed randomized trial, Radiation Therapy and Oncology Group Trial 9508, compared whole brain radiotherapy (WBRT) with WBRT + stereotactic treatment for patients with 1-3 brain metastases, and found an overall survival advantage only in patients with a single metastasis and those patients in the most favorable baseline recursive partitioning analysis (RPA) prognostic group [ 13].
Similar(57)
The most frequently tested agents were identified and assessed for relevance by use of the following parameters: Only phase 1 studies investigating systemic treatments with dose seeking were selected, whereas phase 1 2 trials, radiation therapy trials, intra-tumoral or loco-regional treatments (e.g. intra-peritoneal injections) trials and organ impairment studies were excluded.
While subunit vaccines have shown partial efficacy in clinical trials, radiation-attenuated sporozoites (RAS) remain the "gold standard" for sterilizing protection against Plasmodium infection in human vaccinees.
The study population consisted of 116 patients enrolled in a phase III randomized clinical trial comparing radiation alone versus radiation plus concurrent chemotherapy for advanced head and neck cancer [ 31] plus an additional 23 patients who met all the entrance criteria but declined enrollment.
RTOG 85-31 was a phase III randomised trial of radiation therapy alone vs radiation therapy, followed by adjuvant goserelin for life.
Lag time-P was defined as the interval from publication of phase I trial without radiation until the opening of a phase I trial with radiation.
Lag time-O was defined as the interval from the opening of the phase I trial without radiation until the opening of a phase I trial with radiation.
Ironically, presuming the successful completion of the RTOG 0848 trial, if radiation improves local control, but not survival, we may have to revisit the radiation therapy question when better systemic control is finally achieved.
The strategy of definitive chemoradiation with selective surgical salvage in locoregionally advanced esophageal cancer was evaluated in a Phase II trial in Radiation Therapy Oncology Group (RTOG -affiliated sites.
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