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Two independent reviewers extracted data while three assessed trial quality.
Trial quality was assessed using the GRADE system.
To assess whether the reported trial quality or trial characteristics are associated with the trial outcome.
Trial quality was evaluated by assessing randomization, allocation concealment, blinding, and handling losses.
Trial quality ranged from good to poor and considerable heterogeneity was present in the study features.
All larger trials (N>100) were at high risk commercial sponsorship bias, otherwise trial quality was mixed.
The trial quality was poor, with a lack of blinding, and unstated UTI definitions were almost universal.
Trial quality was assessed using the modified Jadad scale and the Consolidated Standards Of Reporting Trials (CONSORT) checklist.
Clinical trial quality of psychopharmacological studies has changed significantly in most of the aspects we analyzed.
However, evidence linking location with trial quality appears limited to case reports of individual studies.
We postulated that location may negatively impact on trial quality in regions where resources are scarce.
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