Former colleagues also recalled that Mr. Garland insisted on doing the investigation by the book, like obtaining subpoenas even when phone and truck rental companies volunteered to simply hand over evidence, to avoid any future trial problems.
Pertinent clinical trial problems were identified and solutions sought.
When they cannot do so, for example, when working within the protocol of a clinical trial, problems of workability and integration ensue.
Because muscular activities appear during the FRP relaxation phase in case of LBP subjects, the determination of the relaxation phase limits automatically is a non-trial problem for this kind of patients compared to healthy subjects.
In all three trials, problem drinkers who received the CYD intervention displayed significant reductions in alcohol consumption compared to those in the control conditions.
Where we downgraded outcome evidence for risk of bias concerns, these design limitations had to do with the trials' problems with other bias domains, not lack of blinding.
In individually randomised trials, problems of skewness and small sample sizes have sometimes resulted in confidence intervals with poor coverage properties (such as negative lower limits for mean costs).
Our study is the first exclusively online randomized controlled trial among problem gamblers with a naturalistic recruitment in their gambling environment.
Knowing how a beer brand solved a trial generation problem in Australia might trigger an innovative solution on how to generate trial for a brand of mouthwash in the US.
Nonetheless, even after central mandatory review at baseline of a trial, the problem still exists at the next level.
