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The second trial, presented here on 20 May at the American Society for Microbiology's general meeting, was based on the controversial idea that Gulf War veterans' problems are caused by a bacterium called Mycoplasma fermentans.
We then compared the immunogenicity results from this trial with the second trial presented here, which involves vaccination with BCG alone (NCT00480714).
However we believe the promising immunogenicity in the short boosting interval trial presented here justifies the further evaluation of this vaccine in efficacy trials as discussed below.
The aim of the first clinical trial presented here was therefore to investigate the safety and immunogenicity of boosting BCG induced immune responses with MVA85A four weeks after BCG vaccination (NCT00427453).
The primary outcome measure in the short interval BCG MVA85A trial presented here was safety and the secondary outcome was vaccine induced cellular immune responses, as measured by an ex-vivo IFN-γ ELISpot assay.
The aim of the clinical trial presented here was to investigate the safety and immunogenicity of boosting BCG vaccinated subjects with BCG, and to compare these results with data from previous trials where BCG vaccinated subjects had been boosted with MVA85A [24].
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On the basis of Trial 1 and 2 and some preliminary outdoor studies (not shown here) we estimated the dose of Se for outdoor longer-term trial test presented here.
The drug Taxotere can extend the lives of prostate cancer patients after hormonal therapy fails, giving men a new last-ditch option for treatment, according to the results of two clinical trials presented here Monday.
But late-stage trials presented here at the annual meeting of the American Heart Association were promising enough that Acorn plans to file for marketing approval with the U.S. Food and Drug Administration by Dec. 10, with hopes of a decision in 2005.
Consequently, results of the murine trials presented here should be interpreted within these limitations.
All subjects enrolled in the trials presented here were negative on an ex-vivo Elispot assay for the two M.tb specific antigens ESAT6 and CFP10.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com