Recently, radiation has been used in combination with immunotherapy in various clinical trials, predominantly with checkpoint inhibitors to re-invigorate T cells9.
Insertional oncogenesis due to retroviral (RV) vector integration has caused recurrent leukemia in multiple gene therapy trials, predominantly due to vector integration effects at the LMO2 locus.
The trials predominantly recruited older children and adults.
Clinical trials, predominantly single-center studies, have shown conflicting results.
The trials predominantly including stage III patients are generally older than those including stage II patients.
There was some statistical heterogeneity, with two trials (predominantly from trial sites in Thailand) finding slightly higher levels of treatment failure with AS+MQ.
The side effects were almost the same in the two trials, predominantly nausea and diarrhea, while anemia and thrombocytopenia represented the main hematologic toxicity.
For the ARBs, evidence for guideline recommendations came from a number of clinical trials (predominantly in patients with chronic kidney disease) that showed ARBs to be renoprotective, independent of their BP-lowering effects (Table 4).
Nonetheless, most of the clinical trials, predominantly with bisphosphonates, were done on people many or most of whom had spinal compression fractures and better fitted the trabecular bone loss model.
35 However, our recruitment strategy was similar to that in most of the other trials, our entry routes were equivalent to other trials (predominantly through the attenuated symptoms pathway), and our baseline levels of psychotic experiences and functioning (for example, global assessment of functioning scores) were also similar to those of the other trials.
