The results of pre-trial potency testing revealed that both FP9 and MVA ME-TRAP were as immunogenic as expected based on previous assays of these vaccines, producing on ELISPOT a mean number of 125 spot forming units (sfu) per 106 splenocytes (standard deviation, SD 59.7), and 554 splenocytesenocyteSD(SD 118) respectively (mean of results from 4 individual mice for each vaccine).
When HSV-2 gD has been used as a subunit vaccine in human clinical trials, the potency of the resulting gD2-antibody response does not correlate with protective immunity against HSV-2 [56], [57], [57].
A number of different criteria have been proposed for the selection of genetic inhibitors for advancement to human clinical trials, including potency of inhibition, lack of immunogenicity, lack of toxicity, and the propensity for evolution of resistant viruses [5], [6].
Controlled Trial of Homoeopathic Potency, with Pollen in Hayfever as Model.
controlled trial of homoeopathic potency, with pollen in hayfever as model," Lancet, October 18 , 1986 ii: 881-6.
Addressing questions about efficacy, the panel noted that the anthrax bacterium is so dangerous that it would be unethical to test the potency of the vaccine in clinical trials.
At least 8 concentrations were included in the potency trials, and each concentration was tested with 8 replicates in 3 independent trials.
The introduction of lipid nanoparticle bupivacaine has paved a way for several randomized trials investigating the potency and safety of this new delivery system (Table 3).
Our study was partially motivated by these aspects of the trials of higher potency versus lower potency statins.
The overall rate ratio for current treatment that we observed in our analysis of statins and diabetes (rate ratio 1.15) was similar to the relative risks reported in the meta-analyses by Rajpathak et al (relative risk 1.13), 2 by Sattar et al (odds ratio 1.09), 3 and by Preiss et al in a meta-analysis of trials comparing higher potency and lower potency statins (odds ratio 1.12).
mTOR inhibitors have been tested successfully in clinical trials for their antineoplastic potency and well tolerability.
