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Experimental results of a prototype UUV executing the coordinated mission of following the perimeter of the trial pool are reported and discussed.
Abbas does not however consider the recruitment of trial centres - which could have an effect on reducing the effect of exhaustion of the trial pool.
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In the absence of a head-to-head clinical trial, pooled discontinuation and relapse rates were obtained from long-term open-label studies weigthed for different sample size [ 19, 38, 39, 41].
However, a main effect for time was observed whereby HR decreased over time across both trials (60 ± 10 bpm at baseline vs. 52 ± 9 bpm at 300 min post meal in placebo trial; 61 ± 12 bpm at baseline vs. 51±± 9 bpm at 300 min post meal in cinnamon trial; pooled placebo and drug data, p < 0.05).
In the remaining trials, pooled effect sizes were much smaller.
In the PREEMPT trials, pooled safety analyses were undertaken for all patients who received at least one dose of onabotulinumtoxinA or placebo.
A post-hoc comparison of TRs 9 to 11 contrasting non-numbed and numbed trials (pooled for the two rating conditions) revealed a significant difference for this 'late response' (F 1,13) = 6.96, P = 0.02).
These results were obtained with all trials pooled.
The trials pooled in all of the meta-analyses varied widely in the CHD event rates in the control group.
Since this was the case in the statin trials, pooled dispersion values were not applied in this meta-analysis.
However, most randomized trials pooled both grades III or IV astrocytic tumors and grade III oligodendroglial tumors as malignant glioma[ 7, 8].
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