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In addition to being important from a clinical trial perspective for assessing HIV incidence and retention, the feasibility studies provided space for the development of innovative approaches to collecting sensitive information and the opportunity to integrate these into a coherent methodological whole.
From an overall trial perspective, this would present an acceptably small error in data.
Content of these instruments provide insight into the aspects of cough severity considered important from a clinical trial perspective.
From a trial perspective, consideration as to the type of surgical procedure(s) to include must also hinge on currently accepted insurance practices.
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However, it is important to state that this conclusion is true most likely for patients treated within group 3. Since the CAIRO- and the MRC-FOCUS trial, perspectives on curability of disease have changed specifically with regard to the interpretation of surgical respectability [ 26].
Due to features common in studies of delirium (small sample sizes, sample attrition, fluctuation course of the disease and spontaneous recovery), techniques that use all available data and take a global (as opposed to end-of-trial) perspective are preferred [ 87].
Aminoguanidine, a prototype therapeutic agent for inhibition of AGE formation, has received the most interest from a clinical trials perspective [ 4, 5].
Year, trial type (perspective or retrospective), and country were the three features examined [ 6, 7, 9- 13].
From a trial enrichment/biomarker perspective perhaps the most exciting developments have emerged from studies of tumour-derived cell-free DNA (cfDNA) extracted from patient plasma.
StS was principal clinical investigator for the MONIKA register underlying this methodological investigation and contributed a major part of its clinical patient data; furthermore she revised this manuscript draft by bringing in the trial site perspective.
The state of art related to this delicate equilibrium represents the starting point for designing future clinical trials, in perspective of clinical recommendations.
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