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Farms with low or high within-herd prevalence of active DD lesions at trial outset had a mean cow-level prevalence of active DD lesions of 8% (range, 2 to 13) and 31% (range, 18 to 43), respectively.
Winkler points out an additional issue that the editorial misses, required for full transparency in medical literature, namely, the requirement that "authors register clinical trials at trial outset rather than after they determine that the results, or which results, are to their liking".
At trial outset, recruitment was encumbered by the lack of familiarity with and scepticism regarding this procedure in many of the centres.
By contrast, the parameter μ1 is much more elusive; at the trial outset it is a discrete random variable with K possible values and, conditional on Q, it is not unbiasedly estimated by its final stage three MLE: (4 since Y11 and Y12 are conditionally biased with respect to μ1.
Women were randomised to receive fluorouracil600/epirubicin60/cyclophosphamide600 for four cycles followed by docetaxel100 for four cycles (FEC-D) or one of two standard regimens (choice declared by each centre at trial outset): F600E60C600 for eight cycles (FEC) or epirubicin100 for four cycles followed by cyclophosphamide600x2/methotrexate40x2/fluorouracil600x2 for four cycles (E-CMF) [19].
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This was no different from Linneah's reply at the trial's outset two months before.
In addition to its protective effects in nondepressed individuals, the ILI did not appear to harm individuals who had depression symptoms at the trial's outset.
This presupposes that the defendant was not found unfit to stand trial at the outset.
15] to the death sentence conferred in Israel on Adolf Eichmann reflected the equivocal attitude which the German public has displayed toward his trial from the outset.
Sir John said Mr Freeman should have told the second trial at the outset about Mr Ali's earlier conviction and his intention to have it set aside.
Wilders denounced the trial from the outset as politically motivated and an attack on free speech, and initially boycotted the hearings at the high-security court complex in Schiphol.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com