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In addition, the Diabetes Prevention Trial of Type 1 Diabetes (DPT-1) ranks ninth (10 requests).
The Diabetes Prevention Trial of Type 1 Diabetes (DPT-1) study failed to show a protective effect of parenteral insulin (306).
4 The Diabetes Control and Complication Trial of type 1 diabetes, however, found no significant association between frequent severe hypoglycaemic episodes and increased cardiovascular mortality among individuals in the intensive treatment group.
The UKPDS trial of type 2 diabetes observed a 16% reduction in cardiovascular complications (combined fatal or nonfatal MI and sudden death) in the intensive glycemic control arm, although this difference was not statistically significant (P = 0.052), and there was no suggestion of benefit on other CVD outcomes such as stroke.
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How would you feel about a randomized clinical trial of types of breast reconstruction?
On the basis of the success of the trials of type 1 vaccine, WHO contracted with a French vaccine maker to produce tens of millions of doses.
Furthermore, the questionnaires have been used in 15 clinical trials of type 2 diabetes [ 9, 24, 25].
Recently, the results of cardiovascular safety trials of type 2 diabetes drugs, EXAMINE trial with alogliptin and SAVOR-TIMI 53 trial with saxagliptin, were reported [ 49, 50].
A number of clinical trial simulation methods have been used to predict or interpret the results from trials of type 2 diabetes and CVD.
This is in complete agreement with previous adult trials of type 2 diabetes (12) and is reported in individuals with normal and impaired glucose tolerance (24).
Restricting the analysis to trials of ≥24 weeks included three trials of type 1 diabetes that gave no change in HbA1c (−0.01% [−0.22 to 0.25]; I = 0%) and five trials of type 2 diabetes in which HbA1c was 0.79% lower (95% CI 0.15 1.42; I = 83.4%) in metformin versus comparator groups.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com