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In our opinion, two other reasons make a trial of this type potentially appealing.
In addition, we describe the unique challenges of conducting a trial of this type within the setting of the emergency department.
In a trial of this type, it was impractical to use any 'blinding' procedures.
To our knowledge, BIO-RAIDs is the first large prospective trial of this type in the field of CC.
This is the first clinical trial of this type in Japan, designed to analyze two important aspects of Alzheimer's disease (AD) management using medium-chain triglycerides.
This study demonstrates that a trial of this type is feasible in primary care and can be successfully completed with robust trial procedures and high levels of follow up.
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Clinical trials on this type of drug-eluting stents have shown an incidence of restenosis of approximately 4%.
We also outline issues regarding the regulation and design of early clinical trials of this type of molecularly targeted agent.
However, as pointed out by Nash et al [56] trials of this type, more aptly termed "effectiveness trials" (versus the more standard "efficacy trials") clearly have a place in the early stage of treatment development.
Trials of this type were randomly interspersed; the remaining 80% of trials were choice trials.
These factors highlight some of the challenges faced when undertaking long-term longitudinal field trials of this type.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com