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A French trial of this sort is a three-cornered affair.
Mr. Klein called the approval of the first human trial of this sort "an extraordinary benchmark".
A trial of this sort in China is first and foremost a performance, even though it will be closed to the media and the public.
The BBC's Karishma Vaswani, in Indonesia, said it is customary for a trial of this sort to take months before any verdict is expected.
The UK Government's National Health Service recommendation to consume "Five a Day" of fruit and vegetables is an uncontrolled trial of this sort, with one of the assumed benefits being a reduced incidence of cancer (although this is not at all proven).
No large-scale primary care trial of this sort of treatment has been performed.
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OK, I agree it is complex, perhaps too complex for the current methodologies for doing medical trials of this sort.
One man remains ill in hospital.Small, preliminary trials of this sort are intended to find out whether a drug is toxic.
For example, their chemical specificity means that they might not bind to their targets in humans as they do in other species.The MHRA has decided that a working group of experts is now needed to decide how trials of this sort of drug can be handled more safely.
This presentation of HRQL information is quite typical for trials of this sort (the trial was sponsored by the developer of alefacept).
The major limitation in randomised trials of this sort is the impossibility of implementing blinding of the participants or field workers, once they visited the home.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com