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Twenty-six women participated in a double-blind placebo-controlled cross-over trial of single administration of testosterone and placebo.
Royal, R. E. et al. Phase 2 trial of single agent Ipilimumab (anti-CTLA-4) for locally advanced or metastatic pancreatic adenocarcinoma.
Richter JR, Martin TG, Vij R, Cole C, Atanackovic D, Zonder JA, et al. Updated data from a phase II dose finding trial of single agent isatuximab (SAR650984, anti-CD38 mAb) in relapsed/refractory multiple myeloma (RRMM).
The remaining 21 patients were enrolled in a phase II clinical trial of single agent tremelimumab (UCLA IRB# 06-06-093, IND# 100453, clinical trial registration number NCT00471887) administered at 15 mg/kg every 3 months.
In a phase I trial of single agent MK4827 enriched with patients having BRCA1 or BRCA2 mutations, 6 patients, including 5 with BRCA mutation, achieved PR.
A phase II trial of single agent gemcitabine in metastatic oesophageal cancer showed no activity in the 21 patients treated (Sandler et al, 2000).
Similar(51)
A trial of single-dose thromboprophylaxis in this subset may be warranted.
We conducted a phase II trial of single-agent sorafenib in patients with advanced biliary tract carcinoma.
The Gynecologic Oncology Group enrolled 73 patients with recurrent/refractory ovarian cancer to a trial of single-agent sorafenib 17.
The EXPECT trial was a larger trial of single-agent lenalidomide in 54 patients with relapsed/refractory PTCL.
However a phase II trial of single-agent temsirolimus induced prolonged stable disease in 1/16 (6%) RMS patients [99].
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