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Liao, Z. et al. Bayesian adaptive randomization trial of passive scattering proton therapy and intensity-modulated photon radiotherapy for locally advanced non-small-cell lung cancer.
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This remains an issue with on-going human trials of passive immunization where a proportion of participants have developed what has been called vasogenic edema [51].
After 150 trials of passive (inattentive) exposure to the novel image, the monkey was switched to the image discrimination task.
After 150 trials of passive (unattended) exposure to the image, the monkey was engaged in the rapid learning experiment described in the manuscript.
Circulating mesothelin/MPF may have diagnostic potential in mesothelin-positive malignancies [ 12], and tumor cell-associated mesothelin is being used as a target in ongoing clinical trials of passive immunotherapy using immunotoxins [ 13, 14].
Moreover, longer latency to step-through in the first trial of the passive avoidance test and a decrease in wall rearing in the hot-plate test were recorded in O3 prenatally exposed mice.
DJS (100 or 200 mg/kg/day, p.o).-administered normal mice showed significant increase in step-through latency during the retention trial of the passive avoidance task (P < 0.05, Figure 1A).
The non-favorable outcomes of recently completed trials on passive immunization against Aβ with bapineuzumab or solanezumab [ 13, 14] could be explained as a logical consequence of the selection of patients with early symptomatic AD, i.e. patients that very likely already had B-Aβ stage 3 [ 17] indicative for advanced stage Aβ pathology when they started the trial.
Given that the rats had no experience of swimming in the pool before the test trial, the performance on the test trial confirms the effectiveness of passive spatial learning for acquiring information about where a goal is situated.
Repeatability was quantified by five successive trials of the passive and simulated active motions.
The left-hand panel of Figure 3 shows the mean percentages of time spent by the two groups in the four corners of the square arena during the test trial after the completion of passive training.
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