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But sales for the drug peaked at $141 million in 2003 on hopes it also worked for pulmonary fibrosis, after a trial of only 18 patients conducted by Austrian scientists suggested that the drug improved lung function.
The last obstacle to the trial of only the second former head of state ever to be charged with war crimes after Slobodan Milosevic, the late Serbian president—had been removed.Not everyone is happy.
Last year, when Allergan asked the F.D.A. to expand approval to the not-so-obese (essentially doubling the potential patient pool), the request was based on a clinical trial of only 149 patients who had lap bands for one to two years.
Gleevec, an anti-cancer drug, was approved in a trial of only 54 patients because nearly all showed benefit [6].
West et al. carried out a single-center trial of only academic internal medicine physicians, and therefore the study cannot be directly generalized to other centers or physicians.
A small trial of only 66 patients evaluated 1200 mg of aspirin daily compared with placebo as adjuvant treatment for Duke's B2 and C colorectal cancer (HR for survival 0.65, 95% CI: 0.02 18.06, P=0.90) (Lipton et al, 1982).
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The new contract terms restricted the project to a trial run of only 500 colonists, likely dampening the prospect of long term profitability from the venture.
Day three will be a time-trial of only 13 miles.
But these results are based on two trials of only 29 patients.
By contrast, the drug Contrave from Orexigen Therapeutics caused a placebo-adjusted weight loss in various trials of only 3.2percentto5.2percentcent.
Those plans call for a heavy American military presence in the country for at least 18 months, military trials of only the most senior Iraqi leaders and quick takeover of the country's oil fields to pay for reconstruction.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com