The cost effectiveness analysis was conducted in the context of data on program impact from a community-level, cluster-randomized trial of the introduction of ORASEL product through a social franchising program.
Nonetheless, it is important to note that the Medical Early Response Intervention and Therapy (MERIT) Study, a cluster multicentre randomized controlled trial of the introduction of the MET in 23 hospitals in Australia, failed, on direct comparison, to show a significant benefit of METs on several important outcomes [ 14].
Systematic review of trials of early introduction of lipid found no significant difference in outcomes comparing early versus late introduction [ 9].
In this sub-study of the SWAP randomized clinical trial, the introduction of fixed-dose treatment with ABC/3TC lead to increases in plasma levels of E-selectin and sVCAM-1 compared with fixed-dose treatment with TDF/FTC, but the effect was short term and could not be detected after 12 and 48 weeks of follow up.
At 3 months into the trial, the introduction of the 'open access' policy to all women regardless of initially expressed preferences resulted in an increase in patient numbers approached and recruited.
On the basis of trial evidence, the introduction of mass screening for colorectal cancer is unlikely to give rise to substantial economies in the costs of treatment.
But the judge, Colonel Tara Osborn, barred prosecutors from referencing Akbar, saying Akbar wasn't on trial and introduction of such material would "only open the door to a mini trial".
He pointed to a wall that offered what he called "contextual bits": mentions of the Scopes trial; the introduction, in England, of a ten-pound bank note with Darwin's likeness on it; and the briefest nod to the Dover, Pennsylvania, school-board trial, concerning intelligent design, that is winding down right now.
Second, changes in the design and analysis of Phase I trials, the introduction of "targeted" investigational agents that are generally less toxic, and an increase in Phase I trials that combine two or more agents in a novel way have changed the conduct of these trials and decreased fears and apprehensions about participation.
In addition to supporting the National Institutes of Health randomized controlled trials of Ebola treatment (27 ) and vaccines (28 ), CDC staff worked with Sierra Leone authorities to implement a parallel Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE), an adaptive, phased-introduction trial of a vaccine candidate among health workers in that country (8, 9 ).
