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Based on the preclinical interaction between epidermal growth factor receptor inhibitors and radiation, we designed a trial of induction chemotherapy followed by thoracic radiotherapy and concurrent erlotinib.
To address the role of induction TPF in OSCC treated with surgery, we conducted a randomized phase 3 trial of induction TPF followed by surgical resection versus surgical resection in patients with locally advanced OSCC [ 9].
Palumbo et al. and Gay et al. conducted a phase II trial of induction therapy with 4 cycles of bortezomib + pegylated liposomal doxorubicin + dexamethasone followed by tandem ASCT (100 mg/m of melphalan), consolidation therapy with 4 cycles of lenalidomide + prednisone, and maintenance therapy with lenalidomide alone in patients aged 65 75 years (Table 3) [ 35, 36].
A recent trial of induction of labour at term for women identified as high risk for emergency CS (higher the risk score, earlier the induction), found in the treatment group a similar CS rate, a higher vaginal birth rate and a reduced NICU admission and adverse perinatal outcome rate [ 9].
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However trials of induction in other high-risk scenarios have not shown any increase in Caesarean sections, rather the reverse.
In the future, treatment of NPC should be individualized, according to recognized prognostic factors, while recognizing the results of randomized trials of induction and concurrent CCRT.
Larger studies are required, but response evaluation using metabolic imaging might be easier to evaluate in trials of induction chemotherapy alone or new biological agents, before the administration of radiation therapy.
Two trials of induction vs induction plus maintenance treatment in responding patients with advanced NSCLC suggested that treatment could be confined to two or three cycles (Buccheri et al, 1989; Weynants et al, 1997), but none of these trials specifically addressed the question of treatment duration.
The objective radiographic response rate of 73% and the resectability of 73% of all eligible patients in this study agree with the previous trials of induction chemoradiotherapy (Rusch et al, 1993; Sugarbaker et al, 1995; Mathisen et al, 1996; Rice et al, 1998).
Two recent phase III trials of induction chemotherapy followed by resection in patients with stage IIIA disease, including some with T3N0 or T3N1 disease, have reported an improved survival in combined modality group (Roth et al, 1998; Rosell et al, 1999).
We enrolled this patient into a phase II clinical trial (KSCC0802) of induction chemotherapy followed by a hepatic resection for unresectable or marginally resectable CRLM [8].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com