Their primary observation is that the median OS in the control arm was underestimated by >25% in 80% of the trials they examined (12 of 15 trials); by way of contrast, the median PFS or time to disease progression (TTP) was underestimated by 25% in 20% of the trials studied (4 of 20 trials).
Successful trials of this contrast-enhancing technique in micro-CT imaging have shown the importance of three conditions: (1) the effective and efficient penetration of iodine through organic tissues, (2) different X-ray attenuation for different tissues after the staining, and (3) the high resolution of CT images that derived from micro-CT scans (1 50 μm resolution) [ 6, 11].
The new trial of this drug, by contrast, involved patients who were getting treated for the first time.
On each trial the contrast variance of the noise field was multiplied by a scaling factor in order to achieve the target s/n level.
We have designed and performed a major multi-centre trial of teleconsultations in two contrasting centres.
In contrast, a trial of CPT in the Democratic Republic of Congo found large effect sizes (combined depression/anxiety ES = 1.8; post-traumatic stress ES = 1.4) [ 48].
39 By contrast, a trial of estrogen vaginal pessaries versus nitrofurantoin in 171 women found a higher incidence of symptomatic UTI in the estrogen group.
In contrast, a trial of atacicept in combination with MMF and corticosteroids in patients with lupus nephritis was terminated prematurely due to rapid falls in IgG levels after six patients were recruited.
In contrast, a trial of 78 liver transplant patients randomized to conversion from CNI to everolimus by day 30 demonstrated a significant improvement in renal function versus CNI-treated controls, with no increase in rejection 9.
In contrast, a trial of the cold-adapted influenza virus vaccine, FluMist, found that although it could induce modest T-cell responses in children, it did not significantly boost T-cell responses to influenza in adults with T-cell responses induced by natural exposure [ 12].
