And it's survived more of those trials, more often, than anyone would expect of a piece of modern gadgetry.
Because clinical trials, more often than not, fail to give positive (effective treatment) results, it seems reasonable to attempt to learn from others' past experiences before initiating pediatric stroke trials.
Djulbegovic et al. reported that industry-funded trials more often compared innovative treatments to either a placebo arm or no therapy, resulting in a higher proportion of such studies favoring the new intervention [24].
In contrast, industry-sponsored trials more often received comments on supporting documentation submitted alongside protocols.
Industry sponsored trials more often planned subgroup analyses compared with investigator sponsored trials (195/551 (35.4%) v 57/343 (16.6%), P<0.001).
Industry sponsored trials more often planned subgroup analyses than investigator sponsored trials (195/551 (35.4%) v 57/343 (16.6%), P <0.001).
We prespecified stratification of our descriptive analyses by sponsorship and hypothesised, based on results reported by Sun and colleagues, that industry sponsored trials more often planned subgroup analyses.
The monkeys' tendency to abort trials more often when an air-puff could occur indicates that the threat of an aversive outcome impacted behavior.
Registered trials more often specified their funding source (89.9% vs. 57.1%; p < 0.0001), and less often reported statistically significant findings, although this comparison was not statistically significant (68.1% vs. 79.2%; p = 0.07).
There was a non-significant trend indicating that non-industry trials more often received comments related to facilities and research staff (n = 39, 32.0%) compared to industry-sponsored trials (n = 18, 17.3%; RR, 1.60; 95% CI, 0.98 to 2.60).
