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Exact(7)
Despite its strengths, trial limitations should be noted.
The reliability of the results may lend them validity, despite the trial limitations.
12 studies discussed results considering trial limitations or addressing sources of potential bias, and nine studies reported sources of funding.
Trial limitations included failure to use validated outcome measures, lack of long term follow-up, and small sample size.
We made judgements on the quality of evidence for each outcome by looking at trial limitations, inconsistency, imprecision, indirectness and the likelihood of publication bias (Balshem 2011).
The trial limitations include the fact that it is known from previous rehabilitation trials 33 that patients in the control group have a tendency to do physical training due to the focus on the subject in the recruitment process.
Similar(53)
The protocol change regarding patient HbA1c eligibility represents a trial limitation, and presenting the consort diagram and the data interpretation will be more challenging as a result.
As for other phase I/II clinical trials, limitations of this study include its small sample size, limited duration, and exclusion of patients with severe RA.
§Overall 6 lower, 4 unclear and 2 high risk of bias trials; limitations for more than one criterion; possible assessment bias as all trials are unblended.
While most useful in the clinical research setting, particularly for clinical trials, limitations may apply for its use in basic science.
*Overall 8 lower, 10 unclear, and 5 high risk of bias trials; limitations for more than one criterion; no blinded trials; assessor outcome not important for all cause mortality so only one level downgrade.
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