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A large multination confirmative trial is required.
However, a randomized, controlled trial is required to establish efficacy.
An appropriately designed randomised trial is required to confirm this.
A prospective randomised controlled trial is required to assess whether this equates to improved patient outcome.
A large multicentered randomised trial is required to confirm these findings.
A further multicentre, randomised controlled trial is required to confirm these results.
In addition, integrative approach of exposure assessment, epidemiology, and clinical trial is required.
A more extensive trial is required, with valid biomarkers/endpoints [91], to determine efficacy of EPO in acute kidney injury.
A further randomised, placebo controlled, double blinded, parallel clinical trial is required to further investigate the potential of this application.
Every sponsor responsible for a clinical trial is required to provide independent quality assurance by means of audits.
Optimal weights can be estimated from pilot data, but it is an open question how large a pilot trial is required to calculate reliably optimal weights.
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