The internal validity of trials is improved by the use of strict criteria for patient selection.
For future studies on publication bias, it is important that the quality of reporting on design and sponsorship of trials is improved.
Purpose Despite increasing awareness of accrual challenges, it is unknown if accrual of older patients to breast cancer treatment trials is improving.
Furthermore, with increased use of targeted therapy, the risk of toxic effects experienced by participants in phase I trials is improving (Roberts et al, 2004).
When animals' experiences were constrained by behavioural tasks to become similar across repeated trials, the encoding of temporal flow across trials was reduced, whereas the encoding of time relative to the start of trials was improved.
When responses in future trials are improved, this technique might be optional for patients who prefer a single procedure, which could potentially lead to similar results as multiple courses of systemic or intra-arterial chemotherapy.
There is no doubt that clinical trials are improving the outlook of patients with leukaemia and other haematological malignancies.
We found that only a very small proportion of the analyzed RCTs met all ten methodological quality criteria, indicating that many of these studies are at a serious risk of bias, but that these trials are improving with time.
In Los Angeles, USA, trial recruitment was improved by a greater utilisation of Hispanic staff and a Spanish language-based education programme.
Around half of participants had a pre-existing diagnosis of LVSD and were receiving sub-optimal doses of ACEi and β-blockers but in this trial this was improved.
