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The study design of a randomized controlled trial is appropriate for the underlying research question.
Given these results and the programme's broad dissemination, testing the programme in a randomised control trial is appropriate.
For the most accurate measurement of overall antibiotic effect on resistance in communities, a cluster-randomized intervention trial is appropriate (45 ).
The retrospective cohort trial is appropriate, but testing stronger strains of C. difficile, using higher-sensitivity detection methods, and tracking the entire length of stay would more accurately support the authors' conclusions.
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The initial telephone screening procedure implemented in this trial was appropriate, and only one patient required attendance for further screening before a descision could be made; furthermore only one patient refused consent to participate in the trial.
Data sets drawn from studies that involve an intervention trial are appropriate for this RFA; these proposals should address the approach to handling intervention effects when exploring etiologic questions.
Despite these limitations, we believe that the participants of this trial are appropriate subjects to investigate whether exogenous melatonin administered chronotherapeutically can restore patient circadian function, improve sleep quality, health-related quality of life, and survival.
This supports the notion that there may be a genuine difference between the two groups and, assuming that the randomization and conduct of the trial was appropriate, this suggests that early goal-directed therapy may be successful in raising mean arterial pressure by between 9.3 and 18.7 mmHg.
WASHINGTON — The Supreme Court indicated Monday that it might soon have something significant to say about whether and when video coverage of federal trials is appropriate.
This has led some to question whether randomised controlled trials are appropriate in palliative care [ 1, 8].
However, although controlled trials are appropriate for establishing potentially causal associations, more naturalistic studies have the advantage of assessing "real life" situations of patients under treatment.
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