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The phase 1 trial integrated translational research to evaluate PD effects of the drug and downstream effects of inhibiting IFNα in SLE.
19 This trial integrated primary HPV testing into the screening programme in a different manner to our study; in the second screening round, women were screened by primary HPV testing in both arms.
The strength of this study is that is designed to be a pragmatic trial integrated in health care practice thus having good prospect to be a sustainable part of municipal health care.
Although the safety profile of tocilizumab was evaluated in each clinical trial, integrated data across all phase 3 studies [ 1- 5] provide a more comprehensive picture of tocilizumab safety.
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Thus, it is time to propose the design of a therapeutic trial, integrating cardiologists and rheumatologists, in order to further decrease cardiovascular risk.
Further research is necessary to establish efficacy with a larger randomized trial, integrate parents and clinicians, fully validate the problem-solving measure, and identify issues in sustainability.
This study uses baseline data from a cluster randomized trial, integrating oral health into a health promoting school programme (LASH), to describe patterns of oral health status and oral health behaviours among secondary school students in Arusha, northern Tanzania.
33 Third, there were no data on the cost-effectiveness of these studies, and finally, none of the trials integrated their intervention into existing healthcare systems making evaluation of the implementation and dissemination of the study findings problematic.
These trials did not test integrated treatments based on research into the mechanisms that may underlie the comorbidity and probably treated samples with severe alcohol dependence.
Such a model should be further investigated in larger samples and in ongoing pediatric trials integrating tyrosine-kinase inhibitors.
Further validation of these findings is warranted in future clinical trials integrating molecular subtyping in their design.
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