To test this hypothesis we constructed a questionnaire asking for additional information (e.g., amount of time spent with patients, amount of effort invested in the trial, indications of unblinding, expectations during the study).
Though the judge, Jed S. Rakoff, called the rulings tentative and subject to change during the trial, the indication that he will admit the wiretaps is a major victory for the prosecution.
Subgroup analyses were performed based on demographics, characteristics at the trial level, indication, and drug class.
In six trials, the indication for use of magnesium sulphate was the prevention or treatment of eclampsia; for three trials, the indication was fetal neuroprotection, and for two trials, the prevention of preterm birth (see Table 1 and Additional file 5 for effect estimates and forest plots for outcomes in Comparison 1).
This may be particularly of interest in multicenter trials were indication for RRT may differ between centres.
The rates of active TB in adalimumab clinical trials across indications were similar to the rates previously reported.
SIRs for all malignancies were based on 294 malignancies, including lymphomas but excluding NMSC, observed in adalimumab trials across indications (figure 3).
18 Herein we review the currently available data with nilotinib, including preclinical findings, pharmacokinetic data, results from phase I and II trials, possible indications beyond CML, and potential for use in combination therapy.
Robust evidence for clinical efficacy and safety of ranibizumab exists, supported by over 1.7 million patient treatment-years (Novartis, data on file) and evidence from more than 12 500 patients from multiple randomised, controlled clinical trials across indications.
Analysis of adverse events of interest through nearly 12 years of adalimumab exposure in clinical trials across indications demonstrated individual differences in rates by disease populations, no new safety signals and a safety profile consistent with known information about the anti-TNF class.
