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In the next trial, in order to increase (Pleft( n right)) from 9 to 12 units, team size needs to be changed to 54 while keeping the other variables unchanged.
In each trial, a stimulus was presented for 1040 ms, followed by an inter-stimulus interval of 1060 ms, resulting in a total trial length [also known as stimulus onset asynchrony (SOA)] of 2100 ms. An event-related design was used, with a pseudo-randomized trial in order to increase contrast detection efficiency (Liu 2004).
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Adaptive design is regarded as an efficient method for clinical trials in order to increase the success rate of a new drug in development, and recently has been actively discussed among regulatory agencies, industry and academia.
Those involved in the treatment of colorectal cancer should therefore be encouraged to continue to provide optimal patient care and to participate in well designed clinical trials in order to increase the evidence upon which they can base their clinical judgements and in order to make further progress.
There may be a role, certainly in confirmatory trials, to design these as open randomised trials in order to increase their generalisability, but the number of trials where such a design is possible may be limiting.
This study aims to assess safety of these systems on a broader scale, i.e., in a large series of 48 patients investigated in several clinical research sites, including centers naïve to such trials, in order to increase external validity of the reported results.
It was a balance between a) the need to maximize the length of the trials in order to increase the precision on LDS, b) the necessity to avoid long and painful walking sessions, and c) the space limitation of the building (70 m corridor).
Our findings were cross-checked with trial participants in order to increase trustworthiness.
The trials within the set were presented in a pseudorandomized order, where repeats of the same trial were slightly clustered in order to increase design efficiency (Henson 2003).
Clinical trial alert systems are also implemented in order to increase physician participation in clinical trials [ 32] and improve recruitment [ 33, 34].
These multiple approaches need to be investigated in small two-armed principle of concept trials with thorough immune monitoring, in order to increase the clinical efficacy of DC-based cancer vaccines.
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