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This trial suffers from a number of design flaws, not least of which is the fact that delivering two cycles of carboplatin at AUC 9 in addition to six cycles of cisplatin paclitaxel adds a longer duration of chemotherapy and an increased cumulative dose of platinum, thus unbalancing the trial in favour of the research arm, irrespective of the mode of administration.
These issues will always be a matter of judgement and differing opinion, but we feel that the IDMC's role must include an assessment of clinical benefit in addition to looking at the primary endpoint, and it is in everyone's interest that the decision to abandon a trial in favour of the new treatment is taken with the utmost gravity.
Especially for futility analyses, it is important to consider whether the trial can usefully contribute to an overview that could provide a definitive answer, but when the patient population is limited or there are no similar ongoing trials a decision to stop a trial in favour of standard treatment (or no treatment) can, in our view, be appropriate even when there is overall clinical uncertainty.
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Strong evidence, based on adequately designed prospective studies and randomized controlled trials, in favour or against the effectiveness and safeness of induction in women with GDM are missing [ 1, 10].
Early stopping of clinical trials in favour of a new treatment creates ethical and scientific difficulties, which are different from those associated with early stopping due to toxicity or futility.
Both results of the past phase 2 trials and present randomised trial are in favour of EoP when compared to paclitaxel.
There is a clear asymmetry here, in that stopping a trial early in favour of a new treatment is different from stopping a trial with a negative recommendation.
The Pope is the source of Canon law, which directs that allegations of child molestation be investigated in utter secrecy, by a "trial" loaded in favour of clerics who if found guilty are "punished" for the most part by orders for prayer and penitence.
As for the rest, on paper the former double runner-up Cadel Evans is the top favourite to win the Tour: he has the final time trial in his favour and has been the most consistent contender in the mountains 6 And what will happen next?
These progresses and results of ongoing well designed clinical trials argue in favour of further development of PDT with systemic delivery of the drug as a viable therapeutic modality in the near future.
These field trials argue in favour of the strategy of mixing repellent and organophosphate on bed nets to better control resistant malaria vectors.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com