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The recent multicenter STOP-IT trial has reported a mortality rate of 1.2%% for patients with complicated intra-abdominal infection [32].
No included sepsis randomised trial has reported a statistically significant reduction in mortality associated with albumin.
However, neither trial has reported a significant difference in local recurrence between the two approaches.
The ASEPSIS trial has reported that the administration of atorvastatin reduced clinical progression of sepsis but did not improve mortality.
However, only a small trial has reported on the efficacy of anti TNF therapy for EAMs of AS [ 11], and further meta analysis could strengthen this evidence.
An Italian trial has reported a fall in the positive predictive value of screening as a result of using liquid based cytology.
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Multiple studies, including a recent prospective randomized trial, have reported improved outcomes with primary anastomosis.
Fitzpatrick et al. [29] in their randomized controlled trial have reported the average sliding of 7.4 mm with dynamic helical blade group.
Indeed, some hospitals in Africa that took part in the CRASH-2 trial, have reported that TXA is unavailable for routine clinical use.
However, other studies, including the MERIT cluster-randomised trial, have reported no significant effects on CPR rates [ 16- 18].
None of the trials has reported the benefit for low-risk patients in absolute terms.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com