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The trial has highlighted the difficulties facing Western Europeans as they try to coax Ukraine toward liberal democracy and away from the centralized political model in neighboring Russia.
A recent randomised control trial has highlighted the benefit of early ART initiation for TB patients [27].
This trial has highlighted a number of issues with the assessment of research impact.
Further qualitative research undertaken during the trial has highlighted that in some instances women feared the peer counsellor visits and questioned their intentions [ 34].
However, there were worries about a possible prothrombotic effect of COX-2 inhibitors (Bombardier et al, 2000) and the recent withdrawal of rofecoxib due to increased cardiovascular thrombotic risk in the Adenomatous Polyp Prevention on Vioxx (APPROVe) trial has highlighted new safety concerns about this class of drugs.
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The results of individual studies can be conflicting in isolation and the recent results of the ESPAC1 trial have highlighted the need to perform this meta-analysis to assess all available worldwide evidence addressing these questions.
Data stemming from in vitro testing of human cell lines as well as from preliminary trials in diabetic populations, like the Study to Prevent Non-Insulin-Dependent Diabetes Mellitus (STOP-NIDDM) trial, have highlighted – though not undisputed – the potential beneficial effects of the drug on CV morbidity.
The recent controversial US preventative task force report (Lin et al, 2011) giving PSA screening a 'D' rating, prompted by the results from the PLCO and ERSP trials, has highlighted the issues associated with overdiagnosis and overtreatment of PCa.
Translational models and clinical trials have highlighted both the immense challenges involved and some striking examples of success.
These trials have highlighted several toxicities that are attributable to the chemical structure of the ASOs, and not to the particular ASO or target mRNA sequence.
Both the Dunn and Zimmerman trials have highlighted a major theological problem with Stand Your Ground laws.
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