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While prehospital resuscitation has been rigorously tested in other time-sensitive syndromes, such as trauma and cardiac arrest [ 11– 13], no trial has explored the benefit or harm of fluid resuscitation in prehospital sepsis.
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None of the clinical trials has explored the molecular mechanism of the EPO-mediated adverse events.
Although a few trials have explored whether bisphosphonates (BPs) prevented recurrent fragility fractures (FFs), little is known about the secondary preventative effects of BPs.
More recent trials have explored new techniques, including thoracoscopic insufflation of talc and small-bore catheters.
Furthermore, at least two randomized, controlled trials have explored lactate clearance as a potential resuscitation goal for septic shock patients with encouraging results [5, 6].
Several trials have explored whether or not NOS inhibition is effective in allergic bronchitis.
Two positive large trials have explored the chemoprevention of prostate cancer, with cancer incidence as the end point.
No intervention trials have explored the effect of dietary fibre intake on CVD or all-cause mortality risk.
Two other trials have explored a nab-paclitaxel regimen qw 3/4 in combination with bevacizumab for treatment of MBC.
Since then, numerous trials have explored the addition of other drugs in combination with gemcitabine, generally with unimpressive results.
A number of clinical trials have explored the therapeutic potential of retinoids in breast cancer patients or as prevention agents.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com