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Our study was undertaken to attempt to find an optimal trial framework: minimizing the risk of bias, while taking feasibility into account.
Clinical evaluation of HIV vaccine candidates differs from the standard therapeutics trial framework primarily due to the fact that healthy individuals are studied.
The trial framework is to detect superiority of MRE over USS.
In each group, support to participants (known as peers) was facilitated by peer supporters and intended to be non-directive, but operating within the trial framework.
Thirdly, the treatment of the participants in this study following the preliminary assessment will be individualised within the possibilities of a randomised controlled trial framework.
7 15 These studies have all been conducted within a clinical trial framework among depressed patients selected for their high suicide risk.
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Both GDx and SD OCT have recently been employed in neuroprotective trial frameworks 7 allowing neurodegeneration to be quantified in vivo both sensitively and longitudinally.
Rather than try to fit patients, a handful at a time, into the decades-old clinical-trials framework, we'd be far better off changing the trials themselves.
To confirm ON as a sensitive and efficient model for neuroprotection in a clinical trials framework.
The close adherence to a clinical trials framework is a strength of the current study (Kiluk et al., 2011).
It has tested the treatment theories that guide evidence-based treatments using a set of mediation analysis procedures embedded within a clinical trials framework (Nock 2007).
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