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The masked trial fluid was administered in comparable volumes in the HES vs. Ringer's groups in the first 2 days (2250 ml vs. 2500 ml; p = 0.73).
B Braun Medical delivered trial fluid to all sites free of charge.
Secondly, the amount of trial fluid did decrease over time because the percentages of patients who received trial fluid were 94%, 78% and 53% for days 1 to 3, respectively.
First, the exact dose of trial fluid was accounted for in 8,619 of 8,621 99.988%) trial patient-days.
The patients' demographic details, type of surgery, CPB and post-CPB data are summarized in Table 2 according to trial fluid treatment.
In fact, the majority of trial fluid was given within the first 38 hours because day 1 only lasted 14 hours (median).
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We reviewed the existing medical literature using both PubMed and Google Scholar search engines for the primary search terms such as clinical trial, fluids, resuscitation, crystalloids, and colloids and then expanded our search as linked citations indicated.
In the multicenter trial, fluid-yielding ducts were observed in 90% of the premenopausal women, compared with 78% of the postmenopausal women (P < 0.001) [ 3].
The investigator (PW) analyzing the data was blinded to the assigned trial fluids.
The main intervention referred to vasopressors in 38 trials; fluid loading/global hemodynamic-based strategy in eight trials; steroids in eight trials; modulation of immunity in 29 trials; coagulation-targeted therapy in 11 trials; and other adjunctive therapy in four trials.
Currently, the only randomised controlled trial of fluid resuscitation in sepsis is the "fluid expansion as supportive therapy trial" (FEAST) [110].
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