Our trial emphasized outcomes that are reframed as potential acquisition risks to the participant (e.g. new sexually transmitted infections) rather than HIV transmission risks to partners.
However, the lack of protection within the recent Carraguard clinical trial emphasizes how other variables in humans need to be addressed in future study design using macaques in microbicide testing.
The huge variability seen in individual pharmacokinetic profiles in malaria patients, even in the highly controlled environment of a clinical research trial, emphasizes the importance of controlling unregulated use of poor quality drugs, which likely plays a significant role in inducing resistance in low transmission settings [24].
The EGDT trial emphasized that management of the septic patient must begin at the point of diagnosis, which is frequently outside the intensive care unit.
Thus, as a proof of concept, our trial emphasizes that it is indeed possible to titrate and individualize novel therapies in critically ill patients.
A recent study by Kolotkin et al. [ 9] found differences between weight-related and generic measures of health-related quality of life in a one-year weight loss trial, emphasizing the potential value of using more than one measure in a trial, including a disease-specific questionnaire.
An editorial accompanying the FACT trial emphasized that the dose of allopurinol used for comparison (300 mg/day), which could not be modified to preserve the double-blind design, may have been insufficient for a real comparison of the urate-lowering efficacy of these two agents.
The ineffectiveness of vitamins C and E in the prevention of preeclampsia and the potentially harmful effects disclosed by several clinical trials emphasize the need for a better understanding of the underlying mechanisms and metabolism of these antioxidant vitamins in pregnant women.
While these three studies focus on higher brain functions and proprioception, additional trials emphasize autonomic changes occurring with mind and body practices.
As an increasing number of clinical trials emphasize the radiographic progression of the disease as a primary outcome measure [ 5, 33- 35], the capacity to employ a reliable method of scoring radiographs is placed at a premium.
